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About PI

The primary immunodeficiency (PI) diseases are a group of over 150 disorders1, all resulting from defects in immune system function. Although there are a wide range of symptoms and levels of severity, PI is commonly characterized by susceptibility to infection, including frequent, severe and enduring infections. Most PI disorders manifest in the first few months and years of life, although some of the milder diseases may not be identified until adolescence or adulthood.2

Primary immunodeficiency diseases range from fairly common to very rare. Almost all PI disorders are inherited, although the inheritance patterns are not always predictable and, as with all inheritable disorders, may involve environmental factors in some cases.2

Learn more about Primary Immunodeficiency:

These links provide a list of web sites about immune diseases that may be of interest to healthcare professionals. Baxter Healthcare Corporation does not possess editorial control over the content or the information on those other sites. As such, Baxter Healthcare Corporation and the compiler of the list make no representation as to the accuracy, completeness and any other aspect of the information contained in those sites.

Study abstracts have been provided to assist you in selecting literature that may be of interest in your practice. As a professional courtesy, we will be happy to provide full text articles upon request. Please feel free to contact our Medical Information-Professional Services department toll-free at 1-866-4BIOSCI (424-6724).

  1. Geha R, Notarangelo L, Casanova JL, Conley ME, Chapel ME, Fischer A, Hammerstrom L, Nonoyama S, Ochs H, Puck J, Roifman C, Seger R, Wedgwood J. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting. Journal of Allergy and Clinical Immunology 2007; 120(4):776-794.
  2. Blaese RM, Winkelstein J. Patient & Family Handbook for Primary Immunodeficiency Diseases. Towson, MD: Immune Deficiency Foundation; 2007, p.10.